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Title:Marathons for T Cells: How They Keep on Killing
Duration:54:16
Viewed:2,145
Published:21-06-2022
Source:Youtube

Air date: Wednesday, June 15, 2022, 3PM Description: WALS - Wednesday Afternoon Lectures This WALS talk is jointly sponsored with the IIG. Dr. Griffiths is a Wellcome Trust Principal Research Fellow and a professor of immunology and cell biology at Cambridge Institute for Medical Research. For this lecture, Dr. Griffiths will focus on the cell biology that underlies the remarkable ability of cytotoxic T lymphocytes to act as serial killers, with individual cells providing sustained killing in response to cancer or virally infected targets. She will describe a screen that picked up genes that are required for sustained killing and revealed an unexpected role for mitochondria as homestatic regulators of CTL killing. She then will describe work by a former NIH-OxCam student that reveals an (again unexpected) role for transcription during killing. For more information go to oir.nih.gov/wals Author: Gillian Griffiths, Ph.D., Professor of Cell Biology and Immunology, University of Cambridge; Director, Cambridge Institute for Medical Research Permanent link: videocast.nih.gov/watch=44268

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